Glycol ethers are among the most extensively studied and best known chemical substances. They have been used widely since the twenties, enabling to gather considerable information through experience of use. In addition, in-depth studies have been carried out on them in order to best control the risks from their use. Glycol ether manufacturers are always ready to provide the public authorities with any information at their disposal.

Research


Several joint experts’ reports have condensed the results of several hundreds of individual studies on glycol ethers:

  • INSERM. (1999) Ethers de glycol, quels risques pour la santé’ Collection Expertise collective, Editions Inserm, Paris. 348p
  • INSERM. (2005) Ethers de glycol: Nouvelles données toxicologiques’ Collection Expertise collective, Editions Inserm, Paris. 147p
  • Boatman RJ, KnaaK JB. (2001) Ethers of ethylene glycol and derivatives. Fifth Ed. In: Bigham E, Cohrssen B, Powell CH (Eds).
  • Patty’s Toxicology fifth ed. Vol 7, Chapter 86. Wiley Interscience, New York.
  • Boatman RJ, KnaaK JB. (2001) Ethers of propylene glycol and derivatives. Fifth Ed. In: Bigham E, Cohrssen B, Powell CH (Eds). Patty’s Toxicology fifth ed. Vol 7, Chapter 87. Wiley Interscience, New York.


The European Oxygenated Solvent Producers Association (OSPA) contributed towards the financing of  the following reviews:

  • Proceedings of the Third International Scientific Symposium on the Health Effects of Glycol Ethers – 2002. (2005) Toxicology letters, 153(1): 1-226.
  • ECETOC. (2004) The Toxicology of Glycol Ethers and its relevance to Man. Technical Report No. 95, fourth ed., Vols I and II. European Centre for Ecotoxicology and Toxicology of Chemicals, Brussels, Belgium.
  • Kimber I, Pieters R. (2013) Household chemicals, immune function, and allergy: A commentary. Journal of Immunotoxicology, 10: 169-172.
  • Boatman R, Kelsey J, Ball N. (2014) Acute toxicity classification for ethylene glycol mono-n-butyl ether under the Globally Harmonized System. Regulatory Toxicology and Pharmacology, 68: 41-50.
  • Biomonitoring publication


The European Oxygenated Solvent Producers Association (OSPA) also actively monitor newly published literature on glycol ethers. If they do not agree with the content of a publication, letters to the Editors are published:

  • Ball N (2013) Letter to the Editor. Glycol Ethers and Congenital Malformations. Epidemiology, 6: 939-940.
  • Kelsey J (2013) Concerning statements made in ‘Determinants of exposure to 2-butoxyethanol from cleaning tasks: a quasi-experimental study by Bello, A. et al, Ann. Occup. Hyg, Vol. 57, No. 1, pp. 125-135, 2013. Ann. Occup. Hyg, 57:1087-1088.